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[(R,)-244(o)13.7(r)-251.6(no)16.7(n)13.3(c)0(a)20.1(n)0(n)16.3(a)12.8(bi)20.2(no)21.9(id)-244.3(r)12.2(e)0(c)19.8(e)0(p)15.2(t)12.3(o)13.7(r)0(s)19.3(.)]TJ
-9.1927 -1.1795 TD
.0099 Tc
[(These)-551.8(i).9(ncluded)]TJ
/F7 1 Tf
7.0148 0 TD
0 Tc
(D)Tj
/F8 1 Tf
8.2191 0 0 7.3052 146.3244 68.1449 Tm
(8)Tj
10.959 0 0 10.959 150.3496 63.2692 Tm
.0102 Tc
[(-tetrahydro)3.2(c)-3.2(an)2.8(nabino)3.2(l)-552(\()]TJ
/F7 1 Tf
10.0825 0 TD
0 Tc
(D)Tj
/F8 1 Tf
8.2191 0 0 7.3052 268.2708 68.1449 Tm
(8)Tj
10.959 0 0 10.959 272.296 63.2692 Tm
.011 Tc
[(TH)5.4(C\),)]TJ
3.7195 57.9085 TD
.6342 Tc
[(am)623.7(o)627.2(r)620.6(es)625.7(t)625.8(a)626.3(b)622.1(l)625.5(ei)625.2(s)625.7(o)622.1(m)623.7(e)626(ro)627.2(f)]TJ
/F7 1 Tf
11.6086 0 TD
0 Tc
(D)Tj
/F8 1 Tf
8.2191 0 0 7.3052 447.6471 702.7651 Tm
(9)Tj
10.959 0 0 10.959 451.729 697.8896 Tm
.0077 Tc
[(-te)-5.7(t)-.7(ra)-5.4(hy)-5.1(dro)-4.4(c)-.5(a)-5.4(n).3(n)-4.8(a)-.2(bi)-6.5(no)-4.4(l)]TJ
-12.6536 -1.1847 TD
0 Tc
(\()Tj
/F7 1 Tf
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(D)Tj
/F8 1 Tf
8.2191 0 0 7.3052 324.3401 689.7825 Tm
(9)Tj
10.959 0 0 10.959 328.422 684.9069 Tm
.0103 Tc
[(T)3.5(H)-.5(C\),)-216.6(c)2.1(annabidiol)-215.6(\(CB)3.6(D)-.5(\),)-216.6(and)-214.6(t)1.9(he)-215.2(CB)3.6(D)-217.7(d)2.6(erivative)]TJ
-1.4019 -1.1795 TD
.01 Tc
[(HU-308.)-258.3(Both)]TJ
/F7 1 Tf
6.0371 0 TD
0 Tc
(D)Tj
/F8 1 Tf
8.2191 0 0 7.3052 386.6456 676.8565 Tm
(8)Tj
10.959 0 0 10.959 390.6707 671.981 Tm
.0123 Tc
[(TH)6.7(C)-257.7(a)4.4(nd)]TJ
/F7 1 Tf
4.1023 0 TD
0 Tc
(D)Tj
/F8 1 Tf
8.2191 0 0 7.3052 443.055 676.8565 Tm
(9)Tj
10.959 0 0 10.959 447.0802 671.981 Tm
.0107 Tc
[(THC)-254.1(p)3(roduce)-256.2(antinoci-)]TJ
-12.2294 -1.1847 TD
.0096 Tc
[(ceptive)-572.8(e)1.4(ffects)-573.1(i).6(n)-572(p)-3.2(re-clinical)-573.3(m)-.9(odels)-573.1(w)-1.4(ith)-571.6(s)-4(imilar)]TJ
0 -1.1795 TD
.0104 Tc
[(po)3.4(tency)-209.3(v)2.8(ia)-209.6(activation)-209.1(o)3.4(f)-210.7(C)4.2(B)]TJ
8.2191 0 0 7.3052 437.1589 644.2581 Tm
0 Tc
(1)Tj
10.959 0 0 10.959 441.1841 646.0723 Tm
.012 Tc
(R.)Tj
8.2191 0 0 7.3052 450.5385 650.9479 Tm
.0159 Tc
[(22)5.2(2)5.2(6)]TJ
10.959 0 0 10.959 473.329 646.0723 Tm
.0107 Tc
[(CBD)-207(l)-3.1(acks)-204.7(the)-209.6(b)3.7(e-)]TJ
-14.6246 -1.1847 TD
.0091 Tc
[(havior)-4.5(al)-408.2(eff)-5.1(ect)-4.5(s)-402.9(o)-3(f)-408.6(T)2.3(HC)-405.7(at)-408(CB)]TJ
8.2191 0 0 7.3052 453.3164 631.2754 Tm
0 Tc
(1)Tj
10.959 0 0 10.959 457.3983 633.0896 Tm
.0084 Tc
[(R,)-409.9(and)-407.9(m)-2.1(ay)-407.9(pr)-5.2(oduce)]TJ
-13.1709 -1.1795 TD
.011 Tc
[(ph)4(armaco)4(log)3.4(i)2(cal)-566.7(a)3.1(ctio)4(ns)-566.5(th)4(ro)4(ug)3.4(h)-565.1(t)2.6(he)-561.1(activatio)4(n)-565.4(o)4(f)]TJ
T*
.0104 Tc
[(no)3.4(ncan)3(nabin)3(o)-1.7(id)-519.8(receptors.)]TJ
8.2191 0 0 7.3052 435.5148 612.0565 Tm
.0168 Tc
[(27)6.1(29)]TJ
10.959 0 0 10.959 461.707 607.2377 Tm
.0105 Tc
[(HU-308)-519.3(i)1.5(s)-520.5(a)-519.9(selec-)]TJ
-13.5641 -1.1847 TD
.4924 Tc
[(t)478.8(i)483.4(v)484.8(e)-2.1(a)484.5(n)485(dh)485.4(i)483.4(g)479.6(h)485.4(l)483.7(yp)484.7(o)480.3(t)484(e)484.2(n)479.9(ta)484.5(g)479.6(o)485.4(n)485(i)478.2(s)483.9(t)2.9(a)484.5(t)2.9(C)481.1(B)]TJ
8.2191 0 0 7.3052 488.6361 592.4408 Tm
0 Tc
(2)Tj
10.959 0 0 10.959 492.6613 594.2549 Tm
.012 Tc
(R,)Tj
8.2191 0 0 7.3052 502.0156 599.1306 Tm
.0107 Tc
(30)Tj
10.959 0 0 10.959 515.3384 594.2549 Tm
.0131 Tc
[(an)5.7(d)-480.8(h)6.1(a)5.2(s)]TJ
-18.4579 -1.1795 TD
.0093 Tc
[(pre)-4.1(v)1.7(ious)-4.3(ly)-308.7(been)-313.6(shown)-308.4(t).9(o)-313.2(r).8(ed)]TJ
12.1776 0 TD
.008 Tc
[(uc)-5.4(e)-310.6(l)-.7(ip)-4.8(op)-4.8(oly)-4.8(s)-.5(a)-5.1(cch)-4.2(ari)-6.2(d).3(e)-5.4(-)]TJ
-12.1776 -1.1847 TD
.0083 Tc
[(i)-5.9(n).9(d)-4.5(u).6(c)-5.1(e).1(d)-299.4(i)-5.9(ntr)-5.3(a).4(oc)-5.1(ula)-4.8(r)-300.2(in)-4.2(a)-4.8(mm)8.3(a)-10.1(t)-.1(io)-3.8(n.)]TJ
8.2191 0 0 7.3052 467.9432 573.2219 Tm
.0176 Tc
(19)Tj
/F5 1 Tf
10.4607 0 0 10.4607 313.0582 542.4377 Tm
/Cs8 cs 1 scn
0 Tc
[(Materials)-302.5(and)-303.8(Methods)]TJ
/F9 1 Tf
0 -1.2357 TD
[(Experimental)-302.2(animals)-299.6(and)-298.4(corneal)-295.5(injury)-304.6(model)]TJ
/F8 1 Tf
10.959 0 0 10.959 313.0582 516.529 Tm
0 0 0 rg
[(All)-246(animal)-242.8(care)-244.9(and)-245.4(experimental)-245.4(procedures)-245.6(complied)]TJ
0 -1.1795 TD
[(with)-257.9(the)-261.6(Canadian)-257.9(Council)-255.8(for)-262.5(Animal)-256.6(Care)-258.4(guidelines)]TJ
T*
[(\(www.ccac.ca/\))-417.3(and)-416.1(were)-413.6(approved)-413.9(by)-412.9(the)-416.8(Dalhousie)]TJ
0 -1.1847 TD
[(Un)18.1(i)11.7(v)0(e)20.4(r)0(s)19.3(i)0(t)18.8(y)-514.6(Co)23.1(m)10.2(m)10.2(i)0(t)18.8(t)12.3(ee)-507.9(on)-505.8(La)21.3(bo)22.3(ra)19.8(to)20.8(ry)-507.5(An)22.6(im)21.8(al)19.7(s.)-509.5(M)10.7(a)12.8(le)]TJ
0 -1.1795 TD
[(BA)18.1(LB)22.5(/c)-410.4(\(2)20.2(0)21.6(30)-149.1(g)13.1(;)-423.5(C)14.5(h)0(a)16.1(r)12.2(l)12(e)0(s)-409.8(R)0(i)20.4(v)0(e)20.4(r)-422.3(La)21.3(bo)22.3(ra)19.9(to)20.8(ri)18.7(es)-409.8(I)12.3(n)0(t)20.5(e)0(r)19.5(n)0(a)15.8(-)]TJ
0 -1.1847 TD
[(ti)18.8(on)21.9(al)19.7(,)-226.9(I)12.3(nc)20.6(.,)-215.8(W)11(i)11.7(lm)17(i)11.7(n)0(g)21.3(t)0(o)20.8(n)0(,)-213.6(M)10.7(A\))-216.7(a)12.8(n)0(d)-211.6(C)0(B)]TJ
8.2191 0 0 7.3052 475.8235 449.9715 Tm
(2)Tj
10.959 0 0 10.959 479.6219 451.7857 Tm
[(R)-224.1(k)0(n)21.2(o)0(c)15.9(k)13.1(ou)21.6(t)-225.7(m)10.2(i)11.7(c)0(e)]TJ
-15.1988 -1.1795 TD
[(\(C)16.1(B)]TJ
8.2191 0 0 7.3052 330.066 437.0456 Tm
(2)Tj
10.959 0 0 10.959 333.9211 438.8597 Tm
(R)Tj
/F6 1 Tf
8.2191 0 0 7.3052 339.5338 443.7353 Tm
()Tj
/F8 1 Tf
.6484 0 TD
(/)Tj
/F6 1 Tf
.3104 0 TD
()Tj
/F8 1 Tf
10.959 0 0 10.959 353.7637 438.8597 Tm
[(\))-458.8(w)0(e)22.1(r)0(e)-446(u)0(s)20.1(e)0(d)-450.4(f)11.6(or)-450(e)12.5(x)0(p)20.6(e)0(r)19.5(i)0(m)16.7(e)12.5(nt)20.5(s.)-447.5(CB)]TJ
8.2191 0 0 7.3052 502.866 437.0456 Tm
(2)Tj
10.959 0 0 10.959 506.6644 438.8597 Tm
(R)Tj
/F6 1 Tf
8.2191 0 0 7.3052 512.277 443.7353 Tm
()Tj
/F8 1 Tf
.6553 0 TD
(/)Tj
/F6 1 Tf
.3104 0 TD
()Tj
/F8 1 Tf
10.959 0 0 10.959 531.666 438.8597 Tm
-.011 Tc
[(mic)-11(e)]TJ
-19.9478 -1.1847 TD
0 Tc
[(we)17(r)12.2(e)-566.9(o)13.7(b)0(t)20.8(a)0(i)19.3(n)0(e)20.7(d)-566.4(by)-552.6(cr)19.5(os)20.8(si)18.7(n)13.3(g)-566.3(m)10.2(a)12.8(le)-554.9(C5)17.6(7)13.4(B)0(L)17.3(/)11.6(6J)-554.4(CB)]TJ
8.2191 0 0 7.3052 528.4912 424.0629 Tm
(2)Tj
10.959 0 0 10.959 532.3463 425.877 Tm
(R)Tj
/F6 1 Tf
8.2191 0 0 7.3052 537.9589 430.7527 Tm
()Tj
/F8 1 Tf
.6484 0 TD
(/)Tj
/F6 1 Tf
.3104 0 TD
()Tj
/F8 1 Tf
10.959 0 0 10.959 313.0582 412.9511 Tm
[(m)10.2(i)0(c)19(e)-396.2(\()11.9(s)0(t)19.3(r)0(a)19.8(i)0(n)-383.7(B)0(6)17(.)11.1(1)13.4(2)0(9)16.5(P)13.6(2-)20.8(Cn)17.5(r)12.2(2)0(t)20.5(m)10.2(1D)23.3(ge)20.4(n/)14.6(J)11.6(;)-392.4(Ja)19.2(ck)20.4(so)20.8(n)-395.3(L)0(a)21.3(b)0(o)17.1(-)]TJ
0 -1.1847 TD
[(ra)19.8(to)20.8(ry)20.2(,)-444.2(B)0(a)21.6(r)-443(Ha)22.7(rb)20.8(or)20.8(,)-444.2(M)10.7(E\))-429.7(wi)21.3(th)-434.4(i)11.7(n)0(b)21.9(r)0(e)19.5(d)-442.2(BA)23.3(LB)17.3(/)11.6(c)-442.7(f)11.7(e)0(m)17.5(a)12.8(le)]TJ
0 -1.1795 TD
[(m)10.2(i)0(c)19(e)-432.4(\()11.9(C)0(h)17.9(a)12.8(rl)19.1(es)-420.2(Ri)20.4(ve)20.4(r\))-420.8(fo)20.2(r)-432.7(1)0(0)-418.1(g)0(e)20.4(n)0(e)20.6(r)0(a)19.8(t)0(i)18.8(o)0(n)21.9(s)0(.)-421.6(G)0(e)16.9(n)13.3(et)19.6(ic)-420.7(lo)20.6(ss)]TJ
0 -1.1847 TD
[(of)-424.7(CB)]TJ
8.2191 0 0 7.3052 339.7038 372.2456 Tm
(2)Tj
10.959 0 0 10.959 343.559 374.0597 Tm
.431 Tc
(R\()Tj
/F12 1 Tf
1.3761 0 TD
0 Tc
[(Cn)17.9(r)12.2(2)]TJ
/F8 1 Tf
1.9503 0 TD
[(\))-427.8(w)0(a)17.3(s)-432.7(c)12.5(o)0(n)21.9()0(r)20.7(m)10.2(ed)-424.6(v)13.1(i)0(a)-425.6(p)13(ol)20.6(ym)18.1(e)12.5(r)0(a)19.8(s)0(e)-420.2(c)0(h)15.8(a)12.8(i)11.7(n)]TJ
-6.1095 -1.1795 TD
[(re)19.5(ac)20.1(ti)18.8(on)-552.3(g)13.1(e)0(n)20.7(o)0(t)20.8(y)0(p)21(i)0(n)19.8(g)-561.1(us)20.1(in)19.8(g)-561.1(D)0(N)19.5(A)-554.6(ex)14.9(t)12.3(r)12.2(ac)20.1(te)19.6(d)-561.2(f)11.7(ro)20.8(m)-564.1(e)12.5(ar)]TJ
T*
[(pu)15.7(n)13.3(c)0(h)21(e)0(s)-425.4(w)14.8(it)18.8(h)-431.2(a)0(n)-418.8(A)0(c)16.6(c)12.5(us)20.1(ta)19.9(rt)-420.4(II)-420.4(M)10.7(o)0(u)16.4(s)12.2(e)-432.4(G)0(e)22.1(n)0(o)21.9(t)0(y)20.2(p)0(i)19.5(n)0(g)-423.6(K)14.2(it)]TJ
0 -1.1847 TD
[(\(Q)16.3(u)13(a)0(n)15.8(t)12.3(a)-406.2(B)0(i)20.5(o)0(s)20.8(c)0(i)19(e)0(n)20.6(c)0(e)19.8(s)0(,)-400.9(G)14.8(ai)19.3(th)20.8(er)19.5(sb)20.8(ur)20.1(g,)-400(M)10.7(D)0(\))-397.2(a)12.8(cc)19.8(or)20.8(di)19.5(ng)-397.8(t)12.3(o)]TJ
0 -1.1795 TD
[(th)15.6(e)-282.4(m)10.2(an)21(uf)19.5(ac)20.1(tu)20.2(re)19.5(r)18.1(s)-287.8(i)11.7(ns)20.4(tr)19.3(uc)20.3(ti)18.8(on)21.9(s.)-276.8(Pr)20.7(im)16.7(e)12.5(r)-287.8(s)12.2(e)0(q)20.7(u)0(e)20.3(n)0(c)15.5(e)12.5(s)-287.8(w)0(e)22.1(r)0(e)]TJ
0 -1.1847 TD
[(as)-378.5(f)11.7(o)0(l)20.6(l)12(ow)18.2(s)12.2(:)-382.1(m)10.2(o)0(u)16.4(s)12.2(e)-385.8(C)14.5(B)]TJ
8.2191 0 0 7.3052 408.529 307.5023 Tm
(2)Tj
10.959 0 0 10.959 416.6928 309.3164 Tm
[(m)10.2(u)13(ta)19.9(nt)-372.7(fo)20.2(rw)16.7(a)12.8(r)0(d)-373.1(\()0(m)16.9(o)13.7(IM)17.8(R)13.9(0)0(0)21.6(8)0(6)16.5(\))]TJ
-9.4566 -1.1795 TD
(5)Tj
/F10 1 Tf
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()Tj
/F8 1 Tf
.238 0 TD
[(-)-339.2(G)14.8(GG)-327.4(GA)18.9(T)-332.7(C)0(G)19(A)-332.1(TC)18.1(C)-332.1(G)0(T)18.4(C)-332.1(CT)18.1(G)-331.8(T)0(A)18(A)-337.3(G)14.8(T)0(C)-328.5(T)13.9(-3)]TJ
/F10 1 Tf
20.6513 0 TD
()Tj
/F8 1 Tf
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(;)Tj
-21.6032 -1.1847 TD
-.0102 Tc
[(mo)-10.2(u)6.2(s)2(e)-468.5(C)-10.2(B)]TJ
8.2191 0 0 7.3052 359.6598 281.5936 Tm
0 Tc
(2)Tj
10.959 0 0 10.959 368.6172 283.4078 Tm
[(wi)21.3(ld)19.9(-t)19.7(yp)21(e)-463.4(\()11.9(W)11(T)0(\))-450.1(f)0(o)20.2(r)0(w)21.9(a)0(r)19.8(d)-462.9(\()11.9(o)0(I)20.8(M)10.7(R7)17(5)13.4(5)0(2)21.6(\))-464(5)]TJ
/F10 1 Tf
16.1558 0 TD
()Tj
/F8 1 Tf
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(-)Tj
-21.4687 -1.1795 TD
[(GG)19.2(A)-487.3(G)0(T)23.5(T)-487.9(CA)23.8(A)-487.3(C)0(C)23.9(C)-487.3(CA)18.7(T)-482.7(G)0(A)18.9(A)-482.1(GG)19.2(A)-487.3(G)14.8(TA)-478.6(C)14.5(-)0(3)]TJ
/F10 1 Tf
21.36 0 TD
()Tj
/F8 1 Tf
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(;)Tj
-21.6032 -1.1847 TD
-.0102 Tc
[(mo)-10.2(u)6.2(s)2(e)-220.2(C)-10.2(B)]TJ
8.2191 0 0 7.3052 356.9385 255.685 Tm
0 Tc
(2)Tj
10.959 0 0 10.959 363.1747 257.4991 Tm
[(co)21(m)10.2(m)10.2(o)0(n)-200.6(r)0(e)19.5(v)0(e)20.4(r)0(s)19.3(e)-215.1(\()11.9(o)0(I)20.8(M)10.7(R7)22.1(55)21.6(2\))-202.3(5)]TJ
/F10 1 Tf
12.2139 0 TD
()Tj
/F8 1 Tf
.238 0 TD
[(-)-215(G)14.8(AC)-203.8(T)13.9(A)0(G)]TJ
-17.0249 -1.1795 TD
[(AG)18.9(C)-357.9(T)0(T)17.5(T)-358.6(GT)18.3(A)-358(G)0(G)24.4(T)-363.7(A)14.5(G)0(G)-353.2(C)14.5(GG)-353.2(G)]TJ
/F6 1 Tf
14.8367 0 TD
()Tj
/F8 1 Tf
.7708 0 TD
(3)Tj
/F10 1 Tf
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()Tj
/F8 1 Tf
.6104 0 TD
-.0174 Tc
[(wi)-17.4(th)-376.2(a)-377.1(s)-17.4(in)-17.4(g)3.9(l)-17.4(e)]TJ
-16.6887 -1.1795 TD
0 Tc
[(pr)14.9(o)13.7(d)0(u)20.9(c)0(t)-394.2(a)0(t)]TJ
/F7 1 Tf
4.6196 0 TD
(*)Tj
/F8 1 Tf
.9881 0 TD
-.014 Tc
[(55)-14(0)-163.1(b)-.3(p)-420(f)-2.4(o)-14(r)-407.1(CB)]TJ
8.2191 0 0 7.3052 437.3857 229.7763 Tm
0 Tc
(2)Tj
10.959 0 0 10.959 441.2408 231.6472 Tm
(R)Tj
/F6 1 Tf
8.2191 0 0 7.3052 446.8535 236.4661 Tm
()Tj
/F8 1 Tf
.6484 0 TD
(/)Tj
/F6 1 Tf
.3104 0 TD
()Tj
/F8 1 Tf
10.959 0 0 10.959 461.0833 231.6472 Tm
[(,)-402.8(a)-401.1(si)18.7(ng)21.3(l)12(e)-406.5(p)13(r)0(o)20.8(d)0(u)15.7(c)12.5(t)-401.6(a)0(t)]TJ
/F7 1 Tf
-13.5072 -1.1847 TD
(*)Tj
/F8 1 Tf
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[(3)13.4(8)0(5)-149.1(b)13.7(p)-199.1(f)11.7(or)-186.2(W)11(T)0(,)-187.1(a)0(n)21(d)-199.1(t)12.3(w)0(o)-183.6(p)0(r)14.9(o)13.7(du)20.9(ct)19.6(s)-199.9(a)12.8(t)]TJ
/F7 1 Tf
13.9676 0 TD
(*)Tj
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