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T*
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(Mortality)Tj
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T*
[(Yes)-20240.3(40)-336(\(42.1\))-5899.3(45)-330.2(\(32.8\))-4500(85)-336(\(36.6\))]TJ
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[(No)-20572.3(25)-336(\(26.3\))-5899.3(29)-330.2(\(21.2\))-4500(54)-336(\(23.3\))-3100.7(0.362)]TJ
T*
[(Yes)-20240.3(70)-336(\(73.7\))-5398.3(108)-331.2(\(78.8\))-3999(178)-337(\(76.7\))]TJ
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T*
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[(No)-21073.3(3)-335(\(3.2\))-6399.3(13)-330.2(\(9.5\))-5000(16)-336(\(6.9\))-3600.7(0.061)]TJ
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T*
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T*
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T*
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[(03)-331.2(Months)-16908.1(32)-336(\(33.7\))-5899.3(21)-330.2(\(15.3\))-4500(53)-336(\(22.8\))-3100.7(0.008)]TJ
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[(36)-331.2(Months)-16908.1(28)-336(\(29.5\))-5899.3(36)-330.2(\(26.3\))-4500(64)-336(\(27.6\))]TJ
T*
[(69)-331.2(Months)-16908.1(10)-336(\(10.5\))-5899.3(21)-330.2(\(15.3\))-4500(31)-336(\(13.4\))]TJ
T*
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[(MMJ,)-335.4(medical)-333.8(marijuana;)-334.1(SD,)-332.8(standard)-332.1(deviation.)]TJ
ET
59.754 178.979 239.131 .22676 re
f
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f
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f
BT
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[(Cost)-17194.2(11)-3261.3(18)]TJ
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[(10)-3261.3(16)]TJ
-19.0262 -2.0212 TD
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T*
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T*
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[(NJMMP,)-335.1(New)-332.6(Jersey)-334.1(Medicinal)-336.3(Marijuana)-329.7(Program.)]TJ
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8.9663 0 0 8.9663 59.7543 749.7069 Tm
[(EFFICACY)-341.6(OF)-331.2(MEDICAL)-339.6(MARIJUANA)-336.3(IN)-335.1(CANCER)-334.5(PAIN)-26443.2(811)]TJ
ET
endstream
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[(0.00)-5.3(1\))-293.3(and)]TJ
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[(\))-397.4(\().1(28)-5.7(/60)-5.7(23)-5.7(/60)-5.7(,)]TJ
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[(0.178\))-279.6(were)-284(not)-279.9(signicant)-284.1(\(Table)-286.7(3\).)]TJ
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[(\))-554(\(7/206/20,)]TJ
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[(\))-473.4(\(7/206/20,)]TJ
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f
BT
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[(Entire)-336.7(Cohort,)-333.6(Severe)-333.8(Pain)-333.2(Sub-Analysis)]TJ
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[(Total)-333.4(coh)-7.3(ort)]TJ
11.5386 1.9092 TD
[(MMJ)-334.4(\()]TJ
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[(\))-3158.7(MMJ)-334.4(\()]TJ
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(n)Tj
/F6 1 Tf
.6663 0 TD
(=)Tj
/F7 1 Tf
.724 0 TD
(137)Tj
/F5 1 Tf
-20.1429 -1.9092 TD
[(Pain,)-334.1(median)-337(\(IQR\))]TJ
.9995 -1.0123 TD
[(Certication)-5856.2(7)-332.9(\(4\))-4824.3(6)-332.9(\(10\))-3632.4(0.126)]TJ
0 -1.0187 TD
[(Most)-338.7(recent)-6027.5(5)-332.9(\(6\))-4824.3(5)-332.9(\(7\))-4132.4(0.142)]TJ
/F7 1 Tf
0 -1.0123 TD
(p)Tj
/F5 1 Tf
11.2439 0 TD
[(0.044)-4579.6(0.005)]TJ
-11.2439 -1.0123 TD
[(MCID)-338.7(improvement)-2080.8(42)-332.6(\(44.2\))-3074.6(60)-332.6(\(43.8\))-2882.4(0.95)]TJ
T*
[(MCID)-338.7(deterioration)-2300.8(29)-332.6(\(30.5\))-3074.6(43)-332.6(\(31.4\))-2882.4(0.889)]TJ
-.9995 -1.3518 TD
[(Physical,)-342(median)-337(\(IQR\))]TJ
.9995 -1.0123 TD
[(Certication)-5356.5(26)-332.6(\(18\))-3824.6(24)-332.6(\(14\))-3632.4(0.075)]TJ
T*
[(Most)-338.7(recent)-5527.8(22)-332.6(\(20\))-3824.6(20)-332.6(\(18\))-3632.4(0.258)]TJ
/F7 1 Tf
T*
(p)Tj
/F5 1 Tf
11.2439 0 TD
[(0.001)-4579.6(0.003)]TJ
-11.2439 -1.0187 TD
[(MCID)-338.7(improvement)-2080.8(56)-332.6(\(58.9\))-3074.6(80)-332.6(\(58.4\))-2882.4(0.933)]TJ
0 -1.0123 TD
[(MCID)-338.7(deterioration)-2300.8(24)-332.6(\(25.3\))-3074.6(39)-332.6(\(28.5\))-2882.4(0.589)]TJ
-.9995 -1.3518 TD
[(Emotional,)-338(median)-337(\(IQR\))]TJ
.9995 -1.0123 TD
[(Certication)-5856.2(6)-332.9(\(10\))-4324.3(6)-332.9(\(11\))-3632.4(0.421)]TJ
T*
[(Most)-338.7(recent)-6027.5(4)-332.9(\(10\))-4324.3(5)-332.9(\(10\))-3632.4(0.817)]TJ
/F7 1 Tf
T*
(p)Tj
/F5 1 Tf
11.2439 0 TD
[(0.193)-4829.5(0.01)]TJ
-11.2439 -1.0123 TD
[(MCID)-338.7(improvement)-2080.8(37)-332.6(\(38.9\))-3074.6(60)-332.6(\(43.8\))-2882.4(0.462)]TJ
T*
[(MCID)-338.7(deterioration)-2300.8(35)-332.6(\(36.8\))-3074.6(39)-332.6(\(28.5\))-2882.4(0.178)]TJ
-.9995 -1.3518 TD
[(Total)-337.2(ESAS,)-338(median)-337(\(IQR\))]TJ
.9995 -1.0123 TD
[(Certication)-5356.5(40)-332.6(\(29\))-3824.6(36)-332.6(\(25\))-3632.4(0.234)]TJ
0 -1.0187 TD
[(Most)-338.7(recent)-5527.8(31)-332.6(\(28\))-3824.6(29)-332.6(\(22\))-3632.4(0.459)]TJ
/F7 1 Tf
0 -1.0123 TD
(p)Tj
/F5 1 Tf
11.2439 0 TD
[(0.001)-4579.6(0.002)]TJ
-11.2439 -1.0123 TD
[(MCID)-338.7(improvement)-2080.8(58)-332.6(\(61.1\))-3074.6(74)-332.6(\(54\))-3632.4(0.287)]TJ
T*
[(MCID)-338.7(deterioration)-2300.8(27)-332.6(\(28.4\))-3074.6(45)-332.6(\(32.8\))-2882.4(0.474)]TJ
-.9995 -1.3518 TD
[(Total)-337.2(morphine)-335.2(eq.,)-340.5(median)-337(\(IQR\))]TJ
.9995 -1.0123 TD
[(Certication)-4606.9(97.5)-332.2(\(150\))-3324.6(45)-332.6(\(135\))-3132.4(0.015)]TJ
T*
[(Most)-338.7(recent)-5028.1(120)-332.3(\(218\))-3324.6(45)-332.6(\(157.5\))]TJ
/F6 1 Tf
23.2694 0 TD
(<)Tj
/F5 1 Tf
.5574 0 TD
(0.001)Tj
/F7 1 Tf
-23.8268 -1.0123 TD
(p)Tj
/F5 1 Tf
11.2439 0 TD
[(0.004)-4579.6(0.522)]TJ
-12.2433 -1.3518 TD
[(Severe)-336.4(pain)]TJ
/F7 1 Tf
12.1793 0 TD
(n)Tj
/F6 1 Tf
.6663 0 TD
(=)Tj
/F5 1 Tf
.7176 0 TD
(49)Tj
/F7 1 Tf
5.4393 0 TD
(n)Tj
/F6 1 Tf
.6663 0 TD
(=)Tj
/F5 1 Tf
.724 0 TD
(61)Tj
-20.3927 -1.0123 TD
[(Pain,)-334.1(median)-337(\(IQR\))]TJ
.9995 -1.0187 TD
[(Certication)-5856.2(8)-332.9(\(2\))-4824.3(8)-332.9(\(2\))-4132.4(0.131)]TJ
0 -1.0123 TD
[(Most)-338.7(recent)-6027.5(7)-332.9(\(6\))-4824.3(7)-332.9(\(6\))-4132.4(0.404)]TJ
/F7 1 Tf
T*
(p)Tj
/F6 1 Tf
10.9684 0 TD
(<)Tj
/F5 1 Tf
.5574 0 TD
(0.001)Tj
/F6 1 Tf
6.2722 0 TD
(<)Tj
/F5 1 Tf
.551 0 TD
(0.001)Tj
-18.349 -1.0123 TD
[(MCID)-338.7(improvement)-2080.8(28)-332.6(\(57.1\))-3074.6(38)-332.6(\(62.3\))-2882.4(0.584)]TJ
T*
[(MCID)-338.7(deterioration)-2800.5(8)-332.9(\(16.3\))-3074.6(10)-332.6(\(16.4\))-2882.4(0.992)]TJ
-.9995 -1.3518 TD
[(Physical,)-342(median)-337(\(IQR\))]TJ
.9995 -1.0123 TD
[(Certication)-5356.5(34)-332.6(\(17\))-3824.6(28)-332.6(\(15\))-3632.4(0.028)]TJ
T*
[(Most)-338.7(recent)-5527.8(22)-332.6(\(21\))-3824.6(23)-332.6(\(17\))-3632.4(0.876)]TJ
/F7 1 Tf
T*
(p)Tj
/F6 1 Tf
10.9684 0 TD
(<)Tj
/F5 1 Tf
.5574 0 TD
(0.001)Tj
/F6 1 Tf
6.2722 0 TD
(<)Tj
/F5 1 Tf
.551 0 TD
(0.001)Tj
-18.349 -1.0187 TD
[(MCID)-338.7(improvement)-2080.8(34)-332.6(\(69.4\))-3074.6(39)-332.6(\(63.9\))-2882.4(0.547)]TJ
0 -1.0123 TD
[(MCID)-338.7(deterioration)-2800.5(5)-332.9(\(10.2\))-3074.6(17)-332.6(\(27.9\))-2882.4(0.021)]TJ
-.9995 -1.3518 TD
[(Emotional,)-338(median)-337(\(IQR\))]TJ
.9995 -1.0123 TD
[(Certication)-5856.2(7)-332.9(\(12\))-4324.3(7)-332.9(\(8\))-4132.4(0.978)]TJ
T*
[(Most)-338.7(recent)-6027.5(6)-332.9(\(10\))-4324.3(6)-332.9(\(12\))-3632.4(0.792)]TJ
/F7 1 Tf
T*
(p)Tj
/F5 1 Tf
11.2439 0 TD
[(0.178)-4579.6(0.055)]TJ
-11.2439 -1.0123 TD
[(MCID)-338.7(improvement)-2080.8(25)-332.6(\(51\))-3824.6(29)-332.6(\(47.5\))-2882.4(0.717)]TJ
T*
[(MCID)-338.7(deterioration)-2300.8(17)-332.6(\(34.7\))-3074.6(18)-332.6(\(29.5\))-2882.4(0.562)]TJ
-.9995 -1.3518 TD
[(Total)-337.2(ESAS,)-338(median)-337(\(IQR\))]TJ
.9995 -1.0123 TD
[(Certication)-5356.5(48)-332.6(\(19\))-3824.6(42)-332.6(\(19\))-3632.4(0.1)]TJ
0 -1.0187 TD
[(Most)-338.7(recent)-5527.8(33)-332.6(\(33\))-3824.6(33)-332.6(\(26\))-3632.4(0.942)]TJ
/F7 1 Tf
0 -1.0123 TD
(p)Tj
/F6 1 Tf
10.9684 0 TD
(<)Tj
/F5 1 Tf
.5574 0 TD
[(0.001)-4297.7(0.077)]TJ
-11.5258 -1.0123 TD
[(MCID)-338.7(improvement)-2080.8(35)-332.6(\(71.4\))-3074.6(33)-332.6(\(54.1\))-2882.4(0.063)]TJ
T*
[(MCID)-338.7(deterioration)-2300.8(11)-332.6(\(21.4\))-3074.6(18)-332.6(\(29.5\))-2882.4(0.404)]TJ
-.9995 -1.3518 TD
[(Total)-337.2(morphine)-335.2(eq.,)-340.5(median)-337(\(IQR\))]TJ
.9995 -1.0123 TD
[(Certication)-4856.8(135)-332.3(\(157.5\))-2574.6(90)-332.6(\(172.5\))-2382.4(0.454)]TJ
T*
[(Most)-338.7(recent)-5028.1(106)-332.3(\(202.2\))-2574.6(60)-332.6(\(236.25\))-1882.4(0.17)]TJ
/F7 1 Tf
T*
(p)Tj
/F5 1 Tf
11.2439 0 TD
[(0.124)-4579.6(0.421)]TJ
-12.2433 -1.3518 TD
[(Mild)-333.8(to)-333.8(mo)-6.7(derate)-331.9(pa)-7.6(in)]TJ
/F7 1 Tf
12.1793 0 TD
(n)Tj
/F6 1 Tf
.6663 0 TD
(=)Tj
/F5 1 Tf
.7176 0 TD
(46)Tj
/F7 1 Tf
5.4393 0 TD
(n)Tj
/F6 1 Tf
.6663 0 TD
(=)Tj
/F5 1 Tf
.724 0 TD
(76)Tj
-20.3927 -1.0123 TD
[(Pain,)-334.1(median)-337(\(IQR\))]TJ
.9995 -1.0187 TD
[(Certication)-5106.6(3.5)-332.5(\(5\))-4824.3(3)-332.9(\(5\))-4132.4(0.721)]TJ
0 -1.0123 TD
[(Most)-338.7(recent)-6027.5(4)-332.9(\(4\))-4824.3(3)-332.9(\(6\))-4132.4(0.319)]TJ
21.4499 -1.685 TD
(\()Tj
/F7 1 Tf
.3332 0 TD
(continued)Tj
/F5 1 Tf
3.9594 0 TD
(\))Tj
ET
313.058 441.298 239.584 .22678 re
f
313.058 720.057 239.584 .22675 re
f
407.055 701.915 120.813 .22681 re
f
313.058 685.19 239.584 .28351 re
f
BT
/F9 1 Tf
8.8489 0 0 8.8489 389.4235 725.499 Tm
(Table)Tj
/F5 1 Tf
3.0048 0 TD
[(3.)-499.3(\()]TJ
/F9 1 Tf
1.5825 0 TD
(Continued)Tj
/F5 1 Tf
4.9012 0 TD
(\))Tj
/F7 1 Tf
-18.1183 -3.8505 TD
[(Total)-339.8(cohort)]TJ
11.5386 1.9092 TD
[(MMJ)-340.8(\()]TJ
/F6 1 Tf
2.7869 0 TD
(-)Tj
/F7 1 Tf
.551 0 TD
[(\))-3158.7(MMJ)-334.4(\()]TJ
/F6 1 Tf
6.2722 0 TD
(+)Tj
/F7 1 Tf
.551 0 TD
(\))Tj
/F5 1 Tf
3.7287 -1.9092 TD
(p)Tj
-13.2492 0 TD
(n)Tj
/F6 1 Tf
.6663 0 TD
(=)Tj
/F7 1 Tf
.724 0 TD
(95)Tj
/F5 1 Tf
5.1895 0 TD
(n)Tj
/F6 1 Tf
.6663 0 TD
(=)Tj
/F7 1 Tf
.7176 0 TD
(137)Tj
-19.137 -1.9156 TD
(p)Tj
/F5 1 Tf
11.2439 0 TD
[(0.078)-4573.2(0.316)]TJ
-11.2439 -1.0123 TD
[(MCID)-332.3(impr)-7.8(ovement)-2073(14)-332.6(\(30.4\))-3081(22)-332.6(\(28.9\))-2876(0.861)]TJ
T*
[(MCID)-332.3(deterior)-10.9(ation)-2289.9(21)-332.6(\(45.7\))-3081(33)-332.6(\(43.4\))-2876(0.81)]TJ
-1.0059 -1.3518 TD
[(Physical,)-342(median)-337(\(IQR\))]TJ
1.0059 -1.0123 TD
[(Certication)-5350.1(22)-332.6(\(15\))-3075(21.5)-338.6(\(16\))-3626(0.705)]TJ
T*
[(Most)-332.3(recent)-4778.2(19.5)-332.2(\(15\))-3831(17)-332.6(\(17\))-3626(0.109)]TJ
/F7 1 Tf
T*
(p)Tj
/F5 1 Tf
11.2439 0 TD
[(0.943)-4573.2(0.075)]TJ
-11.2439 -1.0123 TD
[(MCID)-332.3(impr)-7.8(ovement)-2073(22)-332.6(\(47.8\))-3081(41)-332.6(\(53.9\))-2876(0.512)]TJ
0 -1.0187 TD
[(MCID)-332.3(deterior)-10.9(ation)-2289.9(19)-332.6(\(41.3\))-3081(22)-332.6(\(28.9\))-2876(0.161)]TJ
-1.0059 -1.3454 TD
[(Emo)-7.8(tional,)-336.6(median)-337(\(IQR\))]TJ
1.0059 -1.0187 TD
[(Certication)-5100.2(2.5)-332.5(\(10\))-4330.7(6)-332.9(\(10\))-3626(0.19)]TJ
0 -1.0123 TD
[(Most)-332.3(recent)-6027.5(3)-332.9(\(10\))-4330.7(4)-332.9(\(8\))-4126(0.777)]TJ
/F7 1 Tf
T*
(p)Tj
/F5 1 Tf
11.2439 0 TD
[(0.903)-4573.2(0.073)]TJ
-12.2497 -1.3518 TD
[(MCID)-338.7(improv)-7.2(ement)-3073(12)-332.6(\(26.1\))-3081(31)-332.6(\(40.8\))-2876(0.099)]TJ
0 -1.0123 TD
[(MCID)-338.7(deterioration)-3300.2(18)-332.6(\(39.1\))-3081(21)-332.6(\(27.6\))-2876(0.187)]TJ
T*
[(To)-7.2(tal)-330(ESAS,)-338(median)-337(\(IQR\))]TJ
1.0059 -1.0123 TD
[(Certication)-5350.1(32)-332.6(\(23\))-3075(30.5)-338.6(\(27\))-3626(0.994)]TJ
T*
[(Most)-332.3(recent)-4778.2(30.5)-332.2(\(24\))-3075(26.5)-338.6(\(22\))-3626(0.348)]TJ
/F7 1 Tf
0 -1.0187 TD
(p)Tj
/F5 1 Tf
11.2439 0 TD
[(0.642)-4573.2(0.077)]TJ
-11.2439 -1.0123 TD
[(MCID)-332.3(impr)-7.8(ovement)-2073(23)-332.6(\(50\))-3831(41)-332.6(\(53.9\))-2876(0.672)]TJ
T*
[(MCID)-332.3(deterior)-10.9(ation)-2289.9(16)-332.6(\(34.8\))-3081(27)-332.6(\(35.5\))-2876(0.934)]TJ
-1.0059 -1.3518 TD
[(To)-7.2(tal)-330(mo)-6.7(rphine)-334.8(eq.,)-334.1(median)-337(\(IQR\))]TJ
0 -1.0123 TD
[(Ce)-8.2(rtication)-6347.8(90)-332.6(\(150\))-3331(45)-332.6(\(108.75\))-1875.9(0.01)]TJ
T*
[(Most)-338.7(recent)-6027.5(126)-332.3(\(230.63\))-2081(30)-332.6(\(120\))]TJ
/F6 1 Tf
24.2752 0 TD
(<)Tj
/F5 1 Tf
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(0.001)Tj
/F7 1 Tf
-24.8262 -1.0123 TD
(p)Tj
/F5 1 Tf
12.2497 0 TD
[(0.012)-4573.2(0.935)]TJ
8.7511 0 0 8.7511 321.0519 429.4487 Tm
.0121 Tc
[(eq.,)-450.5(equival)-4.9(e)-.9(nt;)-451.9(E)-2.3(SAS,)-450.5(Edmont)-4.9(on)-446.7(S)-6(y).3(mptom)-457.2(A)4.5(ssessmen)-6.2(t)-451.9(S).5(ys-)]TJ
-.9135 -1.0236 TD
.0115 Tc
[(t)-5.5(e)-1.5(m;)-407.2(IQR,)-405.8(int)-5.5(e)-1.5(rquar)-5.3(til)-5.5(e)-403.1(r)-5.3(ange;)-407.2(M)2.5(CID,)-405.8(mi)-5.5(nim)-4.3(a)-1.5(l)-407.2(c)-1.5(lini)-5.5(cally)-408.4(im)-4.3(por-)]TJ
T*
.0129 Tc
[(tant)-334.5(differences.)]TJ
/F3 1 Tf
8.9663 0 0 8.9663 62.022 749.6502 Tm
0 Tc
(812)Tj
44.6145 0 TD
[(PAWASARAT)-339.5(ET)-338.7(AL.)]TJ
ET
endstream
endobj
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<>stream
/GS1 gs
BT
/F5 1 Tf
9.843 0 0 9.843 59.7543 440.1636 Tm
0 0 0 rg
0 Tc
0 Tw
[(improved)-466.3(between)-467.2(visits.)-465.1(MCID)-462.2(improvement)-466.4(\()]TJ
/F7 1 Tf
20.326 0 TD
(p)Tj
/F6 1 Tf
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(=)Tj
/F5 1 Tf
.72 0 TD
(0.717\))Tj
-21.7083 -1.1116 TD
[(and)-280.9(deteriorati)-10.3(on)-278.7(were)-284(not)-279.9(signicant)-284.1(\()]TJ
/F7 1 Tf
15.8968 0 TD
(p)Tj
/F6 1 Tf
.6624 0 TD
(=)Tj
/F5 1 Tf
.72 0 TD
[(0.562\))-279.6(\(Table)-286.7(3\).)]TJ
-16.2654 -1.1116 TD
[(Mild-moderate)-383.1(MMJ\()]TJ
/F6 1 Tf
8.8872 0 TD
(-)Tj
/F5 1 Tf
.5529 0 TD
[(\))-375.4(\(2.5/203/20,)]TJ
/F7 1 Tf
6.4854 0 TD
(p)Tj
/F6 1 Tf
.6624 0 TD
(=)Tj
/F5 1 Tf
.72 0 TD
[(0.903\))-377.5(slightly)]TJ
-18.3216 -1.1174 TD
[(increased;)-447.7(whereas,)-441.5(MMJ\()]TJ
/F6 1 Tf
10.978 0 TD
(+)Tj
/F5 1 Tf
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[(\))-438.8(\(6/204/20,)]TJ
/F7 1 Tf
5.8576 0 TD
(p)Tj
/F6 1 Tf
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(=)Tj
/F5 1 Tf
.72 0 TD
[(0.073\))-440.9(scores)]TJ
-18.7709 -1.1116 TD
[(improved)-466.3(between)-467.2(visits.)-465.1(MCID)-462.2(improvement)-466.4(\()]TJ
/F7 1 Tf
20.326 0 TD
(p)Tj
/F6 1 Tf
.6624 0 TD
(=)Tj
/F5 1 Tf
.72 0 TD
(0.190\))Tj
-21.7083 -1.1116 TD
[(and)-280.9(deteriorati)-10.3(on)-278.7(\()]TJ
/F7 1 Tf
7.6489 0 TD
(p)Tj
/F6 1 Tf
.6624 0 TD
(=)Tj
/F5 1 Tf
.72 0 TD
[(0.073\))-279.6(were)-284(not)-279.9(signicant)-284.1(\(Table)-286.7(3\).)]TJ
/F3 1 Tf
8.9663 0 0 8.9663 69.7323 360.6802 Tm
[(Total)-261.6(ESAS.)]TJ
/F5 1 Tf
9.843 0 0 9.843 129.3732 360.6802 Tm
[(Bo)19.8(th)-192.4(to)20.7(ta)19.6(l)-202.8(M)0(M)19(J)0(\()]TJ
/F6 1 Tf
6.52 0 TD
(-)Tj
/F5 1 Tf
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-.0208 Tc
[(\))-223.5(\()-20.8(40)-20.8(/8)-20.8(0)-20.8(3)-5.7(1)-20.8(/8)-20.8(0,)]TJ
/F7 1 Tf
6.2608 0 TD
0 Tc
(p)Tj
/F6 1 Tf
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(=)Tj
/F5 1 Tf
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[(0.)18.5(00)20.8(1\))]TJ
-21.7602 -1.1116 TD
[(an)19.7(d)-300.6(M)0(M)19(J)0(\()]TJ
/F6 1 Tf
4.1758 0 TD
(+)Tj
/F5 1 Tf
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-.0208 Tc
[(\))-315.6(\()-20.8(36)-20.8(/)-5.8(8)-20.8(0)-20.8(29)-20.8(/8)-20.8(0,)]TJ
/F7 1 Tf
6.4509 0 TD
0 Tc
(p)Tj
/F6 1 Tf
.6566 0 TD
(=)Tj
/F5 1 Tf
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[(0.)24.3(00)20.8(2\))-290.2(si)20.9(gn)15.1(i)20.9(ca)18.5(nt)20.7(ly)-290.3(im)19.5(pr)20.9(ov)20.8(ed)]TJ
-12.5446 -1.1116 TD
[(be)19.7(tw)14.1(ee)18.5(n)-294.8(v)0(i)20.7(s)0(i)20.9(t)0(s)20.9(.)-297.2(MC)18.9(ID)-285.3(im)19.5(pr)20.9(ov)20.8(em)18.5(en)19.7(t)-295(\()]TJ
/F7 1 Tf
15.0847 0 TD
(p)Tj
/F6 1 Tf
.6566 0 TD
(=)Tj
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[(vi)14.9(si)20.9(ts)20.9(,)-429.6(M)0(M)19(J)0(\()]TJ
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[(\))-448.1(\()-20.8(48)-20.8(/)-5.8(8)-20.8(0)-20.8(33)-20.8(/8)-20.8(0,)]TJ
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[(\))-252.3(\()-20.8(42)-20.8(/8)-20.8(0)-20.8(33)-20.8(/)-5.8(8)-20.8(0,)]TJ
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[(0.)18.5(07)20.8(7\))]TJ
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[(0.)18.5(06)20.8(3\))-313.2(an)19.7(d)-323.6(M)0(C)18.9(I)0(D)-314.1(d)0(e)19.7(t)0(e)19.6(r)0(i)20.7(o)0(-)]TJ
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[(ra)14(ti)20.6(on)-255.6(\()]TJ
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3.0584 0 TD
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[(0.)24.3(40)20.8(4\))-261.4(we)18.8(re)-262.5(no)20.8(t)-271.9(s)0(i)20.9(g)0(n)20.8(i)0()15.1(c)0(a)18.5(n)0(t)-255.8(\()0(T)19.7(a)0(b)13.9(l)0(e)-256.9(3)0(\))20.9(.)]TJ
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[(Mild-moderate)-521.4(MMJ\()]TJ
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9.0312 0 TD
(-)Tj
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[(\))-513.7(\(32/8030.5/80,)]TJ
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7.7641 0 TD
(p)Tj
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[(0.642\))-515.8(and)]TJ
-19.7443 -1.1174 TD
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[(\))-651.9(\(30.5/8026.5/80,)]TJ
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(p)Tj
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[(0.077\))-648.2(improved)-656.4(between)]TJ
-13.2185 -1.1116 TD
[(visits.)-586(MCID)-588.9(improvement)-581.6(\()]TJ
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12.5734 0 TD
(p)Tj
/F6 1 Tf
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(=)Tj
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[(0.672\))-584.9(and)-580.4(deterioration)]TJ
-13.9615 -1.1116 TD
(\()Tj
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(p)Tj
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(=)Tj
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[(0.934\))-279.6(were)-284(not)-279.9(signicant)-284.1(\(Table)-280.9(3\).)]TJ
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8.9663 0 0 8.9663 59.7543 204.4913 Tm
(Discussion)Tj
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9.843 0 0 9.843 69.7323 188.0503 Tm
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-1.0137 -1.1116 TD
[(adjunctive)-435.4(therapy)-436.4(provided)-430.5(analogous)-432.6(symptomatic)-437.6(relief)]TJ
T*
[(without)-325.8(the)-327.1(additional)-324.9(burden)-330.3(of)-324.7(opioid)-323.7(dose)-322.2(escalation.)-330.3(As)]TJ
T*
[(health)-446.9(care)-451.4(providers)-448.7(are)-443.3(caught)-446.8(between)-449.9(providing)-447.9(satis-)]TJ
0 -1.1174 TD
[(factory)-234.7(symptomatic)-241.7(reliefs)-234.7(and)-229.1(protecting)-238.3(against)-234.7(addiction,)]TJ
0 -1.1116 TD
[(MMJ)-459.9(should)-455.8(be)-452.6(considered)-457.9(a)-457.3(viable)-452.7(adjuvant)-460.7(therapy)-453.6(for)]TJ
T*
[(palliative)-285.9(management)-289(in)-278.8(the)-281.1(oncologic)-283.2(population.)]TJ
7.3823 0 0 6.5614 264.5291 126.7086 Tm
(3)Tj
9.843 0 0 9.843 69.7323 111.3448 Tm
-.0164 Tc
[(Cancer)-535.8(su)5.5(rvi)5.4(vor)5.6(s,)-532.4(as)-535.7(many)-530.1(as)-529.9(10)-535.9(y)5.5(ear)5.6(s)-535.7(a)-1.4(f)5.6(t)-.3(er)-530.1(remiss)5.7(ion)5.5(,)]TJ
-1.0137 -1.1116 TD
[(maintain)-196(hig)5.5(h)-.2(er)-196(opi)5.4(oid)-196(prescr)5.6(i)-.3(pt)5.4(ion)-196(r)-.2(at)5.4(es)-201.6(t)5.4(h)-.2(an)-196(pat)5.4(i)-.3(ents)-201.6(with)5.5(ou)5.5(t)-201.9(a)]TJ
T*
[(pri)5.4(or)-230.6(oncolo)5.5(g)-.2(ical)-230.7(di)5.4(ag)5.5(nosi)5.4(s)0(.)]TJ
7.3823 0 0 6.5614 164.6929 93.8268 Tm
-.023 Tc
(16,17)Tj
9.843 0 0 9.843 182.7212 89.4614 Tm
.2144 Tc
[(A)229.7(f)230.6(t)236.2(e)229.4(rat)230.5(h)230.6(r)236.4(e)229.4(s)230.8(h)236.3(o)230.6(l)230.5(do)230.6(f2)236.3(9)63.6(m)235.1(g)230.6(/)230.5(d)236.3(a)229.4(y)]TJ
-12.4928 -1.1174 TD
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[(MME,)-284.5(e)-1.1(v)5.8(e)-1.1(ry)-282.1(ad)5.8(dit)5.7(i)0(on)5.8(al)-282.3(34)-161.2(mg/)5.7(d).1(ay)-282.1(demo)5.8(nst)5.7(r).1(at)5.7(es)-287.7(a)-283.3(s).3(i)5.7(gni)5.7(cant)]TJ
0 -1.1116 TD
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[(dos)5.8(e)-444.8(r)-.1(espon)5.6(se)-444.8(r)5.7(e)-1.3(latio)5.6(nsh)5.6(i)-.2(p)-443.6(w)4.8(ith)-443.6(s)5.8(ubs)5.8(equ)5.6(e)-1.3(nt)-438(opi)5.5(oid)5.6(-)-.1(at)5.5(tri)5.5(but)5.5(ed)]TJ
T*
[(adv)5.5(e)-1.4(rs)5.7(e)-404.6(c)-1.4(l)5.4(i)-.3(ni)5.4(cally)-397.6(meani)5.4(ngf)5.6(ul)-403.5(even)5.5(ts.)]TJ
7.3823 0 0 6.5614 205.3417 60.9449 Tm
-.0239 Tc
(18)Tj
9.843 0 0 9.843 216.3401 56.5795 Tm
-.0156 Tc
[(At)-397(the)-398(t).5(i)6.2(m)-.6(e)-403.8(o)6.3(f)-402.6(M)5.4(MJ)]TJ
9.6014 38.9702 TD
-.0171 Tc
[(cert)4.7(icati)4.7(on,)-181.8(patients)-185(w)4(ho)-185.2(d)4.8(i)-1(d)-185.2(n)4.8(ot)-185.4(us)5(e)-186.4(M)-1.8(MJ)-185([MMJ\()]TJ
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19.3181 0 TD
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(-)Tj
/F5 1 Tf
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[(\)])-185(and)-185(t)4.9(hose)]TJ
-19.8537 -1.1116 TD
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[(w)5.2(h).3(o)-328(u).3(se)4.9(d)-333.8(M)5.1(MJ)-327.8([M)5.1(MJ\()]TJ
/F6 1 Tf
9.2501 0 TD
0 Tc
(+)Tj
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[(\)])-328.6(had)-334.4(a)-329.8(d)5.4(a)-1.5(il)5.3(y)-334.4(o)5.4(piate)-329.8(c)-1.5(o)5.4(n)-.3(su)5.4(mp)5.4(tion)-328.6(o)5.4(f)]TJ
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[(n)6.1(ear)6.2(ly)-230(f)6.2(our)-224.2(tim)4.9(e)-.8(s)-224(a)-.8(nd)-224.2(twi)6(c)-.8(e)-231.2(t)6(his)-224.1(t).3(hr)6.2(esh)6.1(o).4(ld)6.1(,)-226.6(r).4(esp)6.1(e)-.8(c)5(t).2(iv)6.1(ely)6.1(,)-232.3(p)6.1(l).2(ac)5(in)6.1(g)]TJ
0 -1.1174 TD
[(t)6.1(h).5(es)6.4(e)-259.9(p).5(at)6.1(ie)5.1(nts)-258.5(a)5.1(t)-258.8(r).5(is)6.4(k)-258.7(f).5(o)6.2(r)-258.7(ser)6.3(i).4(ou)6.2(s)-258.5(a)-.7(dv)6.2(ers)6.4(e)-259.9(ev)6.2(ent)6.1(s).7(.)]TJ
1.0137 -1.1116 TD
0 Tc
[(The)-201.5(prolonged)-201.2(utilization)-199.5(of)-203.8(opioids)-197.8(is)-203.7(also)-201.3(associated)-205.6(with)]TJ
-1.0137 -1.1116 TD
[(the)-258(development)-259(of)-255.6(tolerance,)-260.1(the)-258(need)-254.4(for)-256.7(higher)-255.5(dosages)-263.1(to)]TJ
0 -1.1174 TD
[(achieve)-231.4(the)-229.2(same)-232.4(degree)-228.9(of)-226.8(relief;)-235(however,)-227.4(the)-229.2(initial)-228.4(effects)]TJ
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[(of)-232.6(tolerance)-233.7(have)-237.1(been)-231.4(postulated)-238.2(to)-232.7(begin)-231.4(after)-238.3(a)-232.6(single)-232.5(dose)]TJ
T*
[(of)-399.6(orally)-399.7(administered)-404(oxycodone.)]TJ
7.3823 0 0 6.5614 450.7086 356.8818 Tm
(18)Tj
9.843 0 0 9.843 461.9904 352.5164 Tm
[(Diminishing)-400.4(the)-402(need)]TJ
-15.3554 -1.1116 TD
[(for)-527.4(high-dose)-535.1(opioids)-531.9(could)-530.9(serve)-531.7(as)-527.3(a)-532.2(protective)-533.2(factor)]TJ
0 -1.1174 TD
[(against)-338.4(severe)-338.2(adverse)-339.3(events,)-340.6(including)-339.8(tolerance)-343.1(develop-)]TJ
0 -1.1116 TD
(ment.)Tj
7.3823 0 0 6.5614 333.0708 323.9999 Tm
(1820)Tj
9.843 0 0 9.843 354.5574 319.6346 Tm
[(Our)-303.6(study)-299.2(found)-305(that)-299.6(the)-304.1(addition)-304.1(of)-301.7(MMJ)-304.4(to)-301.8(pa-)]TJ
-4.4407 -1.1116 TD
[(tients)-268.2(palliative)-268.6(care)-272.8(regimen)-264.8(withstood)-270.2(the)-269.5(development)-270.5(of)]TJ
0 -1.1174 TD
[(tolerance)-325.8(and)-315.5(reduced)-328(the)-321.4(rate)-317.9(of)-319(opioid)-323.7(use,)-318.7(over)-322.3(a)-319(signi-)]TJ
0 -1.1116 TD
[(cantly)-308.7(longer)-307.4(follow-up)-310.5(period)-313.1(than)-305.2(patients)-310.8(solely)-313.1(utilizing)]TJ
T*
[(opioids.)-368.3(Both)-368.4(sub-analyses)-373.3(of)-365(patients)-368.4(using)-368.3(MMJ)-373.5(reduced)]TJ
0 -1.1174 TD
[(daily)-271.9(opioid)-271.8(consumption)-273.8(by)-272.9(33%.)-272.8(Furthermore,)-278.2(by)-272.9(the)-269.5(time)]TJ
0 -1.1116 TD
[(of)-255.6(most)-264.8(recent)-257.9(visit,)-262.6(patients)-264.8(using)-258.9(MMJ)-258.4(who)-263.4(identied)-260.1(with)]TJ
T*
[(mild-moderate)-204.9(pain)-201.5(reduced)-207(their)-202.7(daily)-202.8(opiate)-205(usage)-203.5(to)-198.2(a)-203.8(low-)]TJ
T*
[(risk,)-549.2(low-dose)-552.2(consumption.)-547.9(Unfortunately,)-556.9(this)-545.9(was)-552.3(not)]TJ
0 -1.1174 TD
[(demonstrated)-323.2(by)-319(their)-317.9(counterparts)-327.7(not)-314.5(using)-322.2(MMJ,)-319.4(as)-319.9(their)]TJ
0 -1.1116 TD
[(daily)-243.1(opiate)-245.3(consumption)-250.7(was)-247.1(nearly)-245.2(ve)-246.2(times)-244.1(this)-246.4(value.)-247.5(In)]TJ
T*
[(fact,)-505.6(patients,)-511.2(who)-505.3(did)-504.5(not)-510.3(use)-505.4(MMJ,)-503.7(daily)-508(opiate)-510.3(con-)]TJ
0 -1.1174 TD
[(sumption)-349.9(experienced)-352.1(a)-347.8(statistical)-350.1(and)-350(clinically)-349.2(signicant)]TJ
0 -1.1116 TD
[(median)-338.6(increase)-341.7(of)-342(nearly)-337.3(23%.)-341.9(These)-337.1(ndings)-341.6(were)-341.6(in)-336.4(ac-)]TJ
T*
[(cordance)-203.5(with)-195.6(prior)-201.4(observational)-202.3(and)-194.5(early)-203.8(clinical)-202.9(trials)-198(that)]TJ
0 -1.1174 TD
[(demonstrated)-259.9(similar)-257.9(dose)-258.8(decreases)-263(after)-261.3(the)-258(administration)]TJ
0 -1.1116 TD
[(of)-278.6(cannabinoids)-287.5(to)-278.8(preexisting)-285.3(opioid)-277.6(therapies.)]TJ
7.3823 0 0 6.5614 499.8613 148.6488 Tm
(2123)Tj
9.843 0 0 9.843 320.8251 133.3417 Tm
-.0158 Tc
[(One-fo)-15.8(u)10.8(r).4(th)-546.8(o)-15.8(f)-536.3(patien)-15.8(t)10.7(s)-546.6(tak)-15.8(i)10.7(ng)-546.8(opio)-15.8(i)10.7(ds)-546.6(ach)-15.8(i)10.7(e)-.8(ve)-548(le)-15.8(s)9.8(s)-546.6(than)]TJ
-1.0137 -1.1174 TD
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[(minima)-15.6(l)-284(p).6(a)-15.6(i)9.7(n)-293.2(r)-15.6(e)9.9(l).4(ief)-15.6(.)]TJ
7.3823 0 0 6.5614 387.3826 126.7653 Tm
-.0162 Tc
(24)Tj
9.843 0 0 9.843 397.4172 122.3433 Tm
-.0157 Tc
[(One)-300.2(s).7(t)-15.7(r)10.8(ategy)-299(p).5(at)-15.7(i)10.6(e)-.7(nts)-298.8(w)-.4(i)-15.7(t)10.6(h)-293.3(u)-15.7(n)10.9(c)-.7(ontr)-15.7(o)10.9(lled)]TJ
-8.7951 -1.1116 TD
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[(pain)-195.5(may)-195.5(be)-15.9(n)9.5(e)-.9(t)-195.7(fro)-15.9(m)-180.6(i)-15.9(s)-185.1()52.2(op)-15.9(i)10.6(o).3(id)-195.5(sw)-15.9(i)9.7(t).2(chi)-15.9(n)10.6(g)52.2()-195.5(t).2(o)-195.5(p)-15.9(r)10.7(e)-.9(vent)-195.7(ad)-15.9(v)10.7(e)-.9(rs)-15.9(e)]TJ
T*
[(event)-15.9(s)-300.3(and)-310.7(i).1(ncr)-15.9(e)9.6(ase)-311.9(opi)-15.9(o)10.6(i).1(ds)-15.9()-294.3(a)-15.9(n)9.5(a)-.9(lge)-15.9(s)9.7(ic)-311.9(prop)-15.9(e)9.5(r).3(tie)-15.9(s)9.7(.)]TJ
7.3823 0 0 6.5614 502.2991 104.8252 Tm
-.0239 Tc
(25)Tj
9.843 0 0 9.843 512.4471 100.4598 Tm
-.0157 Tc
[(Howeve)-15.7(r)9.8(,)]TJ
-20.4815 -1.1116 TD
-.0159 Tc
[(the)-381(a)-.9(dv)-15.9(a)9.5(n).3(tage)-15.9(s)-370.4(o).3(f)-379.8()52.2()-15.9(o)10.7(pioi)-15.9(d)-369.6(s).5(witc)-15.9(h)9.5()52.2()-379.8(a)-.9(r)-15.9(e)-370.6(highl)-15.9(y)-363.8(u)-15.9(n)10.7(pred)-15.9(i)10.6(ctab)-15.9(l)10.6(e)-.9(,)]TJ
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[(vary)-16(i)10.5(n).2(g)-328.1(i).1(nde)-16(p)9.4(e)-1(nden)-16(t)10.5(ly)-328.1(betw)-16(e)8.6(e)-1(n)-328.1(p).2(atie)-16(n)9.4(t)0(s)-328.1(sy)-16(m)9.4(p).2(toms)-16(.)-314.1(A)-.7(s)-327.9(s).4(u)-16(c)9.4(h,)]TJ
0 -1.1116 TD
[(nono)-15.9(p)10.7(i).2(oid)-760(a)-.9(dju)-15.9(v)10.7(ant)-760.1(a)-.9(nalg)-15.9(e)9.5(s).5(ics)-15.9(,)-746(inclu)-15.9(d)10.7(ing)-760(aceta)-15.9(m)8.3(inoph)-15.9(e)9.5(n).3(,)]TJ
T*
[(nons)-15.9(t)10.8(e)-.9(roi)-15.9(d)10.6(a)-.9(l)-322.4(a)-.9(nt)-15.9(i)10.4(-).3(in)-15.9()10.9(ammator)-15.9(y)-311.8(dru)-15.9(g)10.7(s).5(,)-324.6(a)-.9(nd)-322.3(co)-15.9(r)10.7(t).1(ico)-15.9(s)10.9(tero)-15.9(i)10.6(d).3(s,)-324.6(ar)-15.9(e)]TJ
ET
q
1 i
110.154 732.245 m
499.521 732.245 l
499.521 493.342 l
110.154 493.342 l
W n
q
389.678 0 0 238.904 110.154 493.342 cm
/Im1 Do
Q
Q
BT
/F8 1 Tf
9.845 0 0 9.845 151.9937 476.5605 Tm
0 Tc
[(FIG.)-336.7(1.)]TJ
/F5 1 Tf
4.1174 0 TD
[(Rate)-335.7(of)-330.2(MME)-334(escalation.)-340.8(MME,)-331.6(morphine)-338.7(milligram)-335.6(equivalents.)]TJ
/F3 1 Tf
8.9663 0 0 8.9663 59.7543 749.7069 Tm
[(EFFICACY)-341.6(OF)-331.2(MEDICAL)-339.6(MARIJUANA)-336.3(IN)-335.1(CANCER)-334.5(PAIN)-26443.2(813)]TJ
ET
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